|
KMID : 0363320040250020195
|
|
Journal of Korean Oriental Internal Medicine
2004 Volume.25 No. 2 p.195 ~ p.201
|
|
|
Antihypertensive effect of Chunghyul-dan(Qingxue-dan) on stage 1 hypertensive patients with stroke
|
|
Yun Sang-Pil
Kim Lee-Dong
Lee Sang-Ho
Kim Eun-Ju
Kim Tae-Hun
Park Young-Min
Jeong Dong-Won
Shin Won-Jun
Jung Woo-Sang
Bae Hyung-Sup
|
|
|
Abstract
|
|
|
Background and Purpose : Hypertension is one of the modifiable risk factors for stroke. Lowering blood pressure is a primary or secondary preventative measure for stroke. This study aims to assess the efficacy of Chunghyul-dan(Qingxue-dan) in stage 1 hypertensive patients who have suffered a stroke by 24 hour ambulatory blood pressure monitoring(24ABPM).
Subjects& Methods : We enrolled 40 hospitalized stroke patients with stage 1 hypertension and divided them into 2 groups by stratified randomization; group A took 1200mg of Chunghyul-dan(Qingxue-dan) at 8:00 a.m. for two weeks without changing herbal medicine, and group B was the control group. 28 patients were included in the final analysis(15 in group A. 13 in group B). Blood pressure is monitored from 8:00 am to 7:30 am every 30 minutes for 24 hours. Blood pressure was monitored two times at baseline and again two weeks later. We used 3 parameters for evaluating the efficacy of Chunghyul-dan(Qingxue-dan); The first parameter is change from baseline to two weeks later in blood pressure and pulse rate. The second parameter is the trough/peak ratio(TPR) and smoothness index(SI). The third parameter is antihypertensive rate by antihypertensive efficacy guideline.
Results : There is no significant difference in the baseline assessment hetween the two groups. Systolic blood pressure (141.37{pm}8.96;mmHg;vs;132.28{pm}9.46;mmHg) decreased after two weeks of 1200mg(P=0.03) intake of Chunghyul-dan(Qingxue-dan). Systolic TPR and SI was 0.87 and 1.04 in group A. Antihypertensive rate was higher in group A.
Conclusion: These results suggest that 1200mg doses of Clunghyul-dan(Qingxue-dan) is an effective antihypertensive agent on stage 1 hypertension patients who have suffered a stroke.
|
|
|
KEYWORD
|
|
|
Hypertension, Stroke, Chunghyul-dan(Qingxue-dan), TPR, SI
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|